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Abstract Ferroptosis is a form of programmed cell death characterized by intracellular iron accumulation and lipid peroxidation, and earlier studies identified glutathione peroxidase 4 (GPX4) as an essential regulator of this process

J Pharm Biomed Anal 7(12):13511360 Castro-Perez J et al (2005) A high-throughput liquid chromatography/tandem mass spectrometry method for screening glutathione conjugates using exact mass neutral loss acquisition

Thus, the leading causes of death in patients with thyroid dysfunctions are the consequences of atherosclerosis acceleration and the worsening of pre-existing cardiovascular and central nervous system diseases (77, 78)

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Phenylbutazone was originally developed for chronic pain for conditions such as arthritis but has since been restricted to treating ankylosing spondylitis due to induction of rare but severe blood disorders, including anemia and leukopenia 86