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On this basis, the presence of microvascular alterations in a pre-diabetic mouse model also suggests that early hyperinsulinaemia and insulin resistance are sufficient to induce vascular damage and that bloodbrain barrier dysfunction precedes cognitive decline (25)

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NPs were found to be efficiently internalized compared with NFs

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Bergles DE, Diamond JS, Jahr CE (1999) Clearance of glutamate inside the synapse and beyond