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17,228,235 These modifications considerably increase nuclease tolerance and prolong the half-life of nucleic acids while effectively avoiding the inflammatory reactions triggered by PS modification, demonstrating a higher safety and activity

Choi WM, Yip TC, Wong GL, Kim WR, Yee LJ, Brooks-Rooney C, Curteis T, Cant H, Chen CH, Chen CY, Huang YH, Jin YJ, Jun DW, Kim JW, Park NH, Peng CY, Shin HP, Shin JW, Yang YH, Lim YS

J Biol Chem 278:5166451672