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NNMT inhibition reduces consumption of nicotinamide (and of S-adenosylmethionine) by blocking the enzyme that would otherwise methylate them

Notably, this low dose outperformed even some existing obesity medications at the time, without the troublesome side effects

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Lactating women have higher daily needs for B vitamins (for instance, riboflavin 1.6 mg/day, niacin ~17 mg NE/day), because some of the maternal intake is secreted in milk to nourish the infant

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