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Potential risks and contraindications Given the limited understanding of DSIPs mechanisms and effects in humans, certain risks and contraindications must be taken into consideration: Unknown long-term effects : The long-term safety of DSIP has not been well-established, and the potential risks associated with chronic use remain unclear

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doi: 10.3389/fmicb.2023.1321386

These include: Opiates/narcotics Antispasmodics Tricyclic antidepressants Anti-diarrheal medications like Alosetron, Lomotil and Imodium Proton pump inhibitors Cholestyramine Preventing methane SIBO relapse As discussed above, methane SIBO is generally less susceptible to relapse than hydrogen-dominant SIBO in our experience