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(1998) Ipamorelin, the First Selective Growth Hormone Secretagogue Eur J Endocrinol 139(5):552561

Late caffeine interferes with sleep initiation for obvious reasons but also reduces slow-wave sleep percentage even when falling asleep seems unaffected, opposing Sermorelin's primary sleep mechanism

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The short dihexa half life is a pharmacological advantage, not a limitation it allows precise temporal control over receptor activation without accumulation toxicity or prolonged systemic exposure