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Consistent with these studies, a recent study in healthy NS workers demonstrated that moderate alcohol consumption further altered peripheral clock gene amplitude in CLOCK, BMAL1, PER1, CRY1, and CRY2, and it was associated with increased colonic permeability, highlighting the compounding effects of environmental circadian disruption and lifestyle factors on peripheral clock gene regulation 143

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As toxicologic pathologists sometimes experience difficulties in distinguishing the wide variety of liver lesions in the rodents for safety evaluation purposes, this document is a consensus of senior toxicologic pathologists regarding suggested nomenclature that should be used for specific lesions