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35 In the Alb-uPA mouse model, uPA, which is controlled by an albumin promoter, converts plasminogen into plasmin inside hepatocytes, causing proteolysis and apoptosis

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Cosmetic ingredient regulation : Topical products are regulated as cosmetics, which the FDA does not pre-approve the way it does drugs

It's banned in the EU due to serious concerns, including ochronosis (permanent skin discoloration) and potential carcinogenic effects.[2] While Europe restricts it severely, hydroquinone remains available by prescription in the U.S.[3] Safer natural alternatives include vitamin C, rosehip oil, aloe vera, licorice root, niacinamide, kojic acid, and neroli extract

Am J Clin Nutr 1998, 68: 380-388