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In a 12-week study in NAFLD patients, every-other-weekly administration of up to 100 mg BFKB8488A, the highest adequately tolerated dose, reduced liver fat by about 40%, serum triglycerides and Pro-C3 by up to 25 to 30% from baseline, while increasing adiponectin by up to 40% and HDL-cholesterol by up to 20% (301)

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MS: Conceptualization, Software, Visualization, Writingoriginal draft, Writingreview and editing

Guideline Statement 8 The IC/BPS diagnosis should be reconsidered if no improvement occurs after multiple treatment approaches

Author Contributions Conceptualization, A.M.H.C