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P53 down-regulates the expression of SLC7A11 to reduce cystine uptake and enhance the cell sensitivity to ferroptosis

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When Wnt pathway activation occurs, Twa1 translocates to the nucleus, and its conserved CRA (CT11-RanBPM) domain is required for its interaction with -catenin, which promotes -catenin nuclear retention and increases Wnt/-catenin downstream target gene expression

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