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(2020) 6:e000928

These CAFs release proteins that build up a dense, fibrous environment around the tumor, creating a lowoxygen, or hypoxic, setting that makes chemotherapy less effective

However, the ROS production is elevated in adipocytes with fat overload ( 4.1 Obesity-induced metabolic dysregulation and OS Excessive adipose tissue accumulation in individuals with obesity leads to a significant increase in plasma free fatty acid (FFA) levels ( 2 - ), thereby inducing OS ( Palmitic acid (PA), the most abundant saturated fatty acid in humans accounting for 20-30% of total fatty acids and widely present in diets ( Figure 2a

& Gamelli, R

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