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Exogenous sources of ROS Exogenous sources of ROS involve radiation, anticancer therapy, smoking, consumption of alcohol, and certain drugs

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For instance, demethylzeylasteral (DML) has been shown to suppress liver cancer stem cell tumorigenicity by inhibiting H3K9la and H3K56la, while royal jelly acid (RJA) inhibits tumor invasion, migration, proliferation, and apoptosis in HCC by targeting H3K9la and H3K14la

Cell Death Dis 8(7):e2921e2921 Bttger EC, Schacht J (2013) The mitochondrion: a perpetrator of acquired hearing loss