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More recently, the use of IPI504 (Retaspimycin, a synthetic derivative of Geldanamycin), in an in vitro model of age-related macular degeneration (AMD) on senescent ARPE-19 (human arising retinal pigment epithelial cells), leads to a decrease of SA--Galactosidase positive cells, associated with a downregulation of senescence-associated gene expression as well as SASPs secretion, suggesting that in some cases HSP90 inhibitors could also be used as senomorphics 27

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Or remains lethargic

Strict abstinence from alcohol is important during treatment, as heavy drinking during treatment has been shown to hinder patients' responses to therapy (8)

Subcellular fractionation experiments confirmed this localization, showing that rHN was not present in microsomal fractions but was found in mitochondrial fractions alongside markers such as Hsp60 and COX I