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Brief centrifugation Before opening the vial, centrifuge it briefly (30 seconds at 1,0002,000 rpm) to consolidate any lyophilized powder that may have migrated to the cap or sidewalls

For patients receiving intramuscular B12 injectionsthe standard treatment for pernicious anaemia and severe deficiency neurological symptoms may start improving within one to two weeks , whilst haematological parameters typically normalise within approximately eight weeks

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