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Multiple cellular processes are considered to contribute to this functional decline and these are collectively referred to as the hallmarks of aging and these include processes like genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis 1

FIGURE 7 3.7 GHK-Cu suppresses inflammatory cytokines partly via STAT3 inhibition We also explored the role of STAT3 in modulating inflammatory factor expression by GHK-Cu in LPS-stimulated MPMs transfected with siSTAT3

Exercise and stress with B-adrenergic stimuli decrease GH secretion by elevating somatostatin tone