By consuming GSH, GPX4 reduces cytotoxic phospholipid hydroperoxides (PLOOH) to harmless phospholipid alcohols (PLOH), thereby blocking the lipid peroxidation chain reaction and maintaining membrane integrity (66)
Similarly, in ovarian cancer cells, CBS inhibition resulted in mitochondrial dysfunction and ROS overproduction (Table 1), consistent with a malfunctioning mETC
Currently, there is limited research specifically focused on glutathione supplementation during pregnancy
Geldanamycin confers fungicidal properties to azole by triggering the activation of succinate dehydrogenase
Diabetol Metab Syndr 4(1):13 Ahn B-I, Kim MJ, Koo HS, Seo N, Joo N-S, Kim Y-S (2014) Serum zinc concentration is inversely associated with insulin resistance but not related with metabolic syndrome in nondiabetic Korean adults