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Data were normalized to the MFI of the vehicle-treated control group and expressed as fold change in relative neuronal gene expression

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doi: 10.1089/jmf.2020.0143 225 ChangH-KShinM-SYangH-YLeeJ-WKimY-SLeeM-Het al

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For established cognitive support, the evidence-based options include aerobic exercise (strong evidence for cognitive benefits, especially executive function and processing speed), sleep optimization (critical for cognitive function), Mediterranean diet (modest evidence for cognitive protection over years), treating sleep apnea (significant cognitive improvements when this condition is addressed), treating depression (major cognitive effects when present), donepezil and other approved Alzheimer drugs (modest evidence-based effects in actual Alzheimer disease), and stimulants (well-established for ADHD)