Materials and methods Human brain tissue and neuropathology The use of post-mortem brain tissues from the BRAIN cohort (Brain Research in Aging, Inflammation and Neurodegeneration) was evaluated by the METc (nr 2021/496) on August 31, 2021, concluding that the protocol is not clinical research with humans as meant in the Medical Research Involving Human Subjects Act
Activated platelets can produce ROS through NADPH oxidase signaling, resulting in the forward-feeding cascade of repeated ROS production and platelet activation and recruitment seen in COVID-19
Compound 968 has an inhibitory effect on GLS2 and can inhibit the growth of BPTES-resistant breast cancer (Lukey et al., 2019), suggesting the different roles of GLS2 in different tumors
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The peptide does not suppress natural hormone production, cause organ toxicity at therapeutic doses, or produce withdrawal effects upon discontinuation