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In a 2017 study published in the Journal of Molecular Medicine , Hsieh and colleagues reported that BPC-157 promoted angiogenesis in chick chorioallantoic membrane and endothelial tube-formation assays and accelerated blood-flow recovery in a rat hindlimb ischemia model, with the effect attributed to activation of the VEGFR2-Akt-eNOS signaling pathway [1]

Interestingly, the ablation of monocarboxylate transporter 1 (MCT1)a lactate transporterfrom OPCs resulted in hypomyelination and axonal degeneration in mature and older (1824-months-old) mice, highlighting the understudied role played by OPCs in myelination among the adult brain (Philips et al., 2021)

doi: 10.1038/s41577-024-01112-7 136 PhanATGoldrathAWGlassCK

Hematol Oncol Clin N Am

Trong qu trnh gii c methylglyoxal, mt sn phm ph c hi ca trao i cht, L-glutathione c glyoxalase I chuyn i thnh S-D-Lactoyl-glutathione v sau glyoxalase II chuyn i thnh glutathione kh v D-lactate