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For context, CagriSema's GI rate was compared to its individual components: semaglutide alone and cagrilintide alone both had lower GI event rates than the combination, consistent with additive GI effects

Supporting this hypothesis, studies have demonstrated that in individuals with increased intestinal permeability, opioid peptides derived from gluten and casein can enter systemic circulation and potentially enhance opioid activity in the brain (Cass et al

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