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However, both genome-wide association studies (GWASs) and candidate gene studies have confirmed an important role for human leukocyte antigen (HLA) class I and class II genes in some but not all forms of DILI

In addition to Frick and Dickey, other researchers at MD Anderson and Ulm University contributed to the study

While we are still a long way away from pinpointing an analogous pathogenic species in MS, once identified, a specific immunotherapy targeting the relevant misfolded proteins, rather than downstream immune effectors as is the current approach, could be more effective in the progressive stages of MS

Heres the whole thing in plain terms: What they did: built and validated a lab-grade method to accurately measure 5A1MQ in the blood, then dosed rats two ways intravenous (IV) and oral and tracked exactly how much showed up in circulation over time

Of course, intravenous is the name for injections into veins