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p = 0.003), IL-23 ( = 0.693

Bjrnson and colleagues estimated that Lp(a) is substantially more atherogenic than LDL on a per-particle basis, with an estimated 6.6-fold greater atherogenicity than LDL (Bjrnson et al., 2024)

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It also enhances cellular permeability, causes DNA damage through the generation of bulky adducts like N2-acetaldehyde deoxyguanine, alters the activity of enzyme convertases, and disrupts cellular oxidative balance by binding to glutathione reductase, resulting in lipid peroxidation and the formation of hydroxyl radicals [184]

Side effects The following side effects attributed to diclofenac were reported