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Nature 543 , 205210 (2017)

Both of these compounds work together to naturally increase the bodys production of human growth hormone (HGH)

Pooling across the field, a 2025 meta-analysis of seven randomized controlled trials, covering 456 participants, reported a standardized mean difference of -0.72 for wrinkle reduction, though the analysis noted high heterogeneity between studies and that roughly 40% of trials had industry funding both factors that warrant caution in interpreting the pooled effect size