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Antioxidants and statins (3-hydroxy-3-methylglutary-coenzyme A reductase inhibitors) A three-year randomized controlled trial in 160 patients with coronary heart disease (CHD) and low high-density-lipoprotein (HDL) levels found that a combination of simvastatin (Zocor) and niacin increased the HDL2 subfraction level (considered the most cardioprotective), inhibited the progression of coronary artery stenosis (narrowing), and decreased the frequency of cardiovascular events, such as myocardial infarction and stroke (130)

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Key sperm parameters affected include motility, concentration, morphology, DNA fragmentation index, and mitochondrial function

Possible Side Effects FOXO4-DRI has been evaluated almost exclusively in preclinical and animal studies, with limited safety data in higher organisms