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The most common adverse effects from the SURMOUNT trials include: Nausea: 24-33% of participants (dose-dependent) Diarrhea: 18-25% of participants Constipation: 13-17% of participants Vomiting: 8-12% of participants Decreased appetite: 10-15% of participants Most of these effects are mild to moderate and occur primarily during dose escalation periods

The second peak, mediated at least in part by NOX1, NOX3 and mitochondrial enzymes, results in prolonged signaling through PI3K, NF-B, and AKT

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High-fat diet induces skeletal muscle oxidative stress in a fiber type-dependent manner in rats