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Baughman RP, Cremers JP, Harmon M, Lower EE, Drent M

Studies have demonstrated that mast cell-deficient models of MS exhibit reduced disease severity, highlighting their pathological role in central nervous system autoimmunity

Persistent senescent cells can propagate the senescent phenotype, resulting in blood-brain barrier breakdown, infiltration of systemic immune cells, neurodegeneration, and gliosis, all of which are observed in the context of AD

In addition, It is well known that melasma is a frequent relapsing pigmentary disorder and treatment of melasma is a life long treatment Cassiano and colleagues

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