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Am J Psychiatry 159(4):663665 Scott F, Hampsey E, Gnanapragasam S et al (2022) Systematic review and meta-analysis of augmentation and combination treatments for early-stage treatment-resistant depression

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The findings indicate that cerebral I/R injury not only causes a specific type of programmed neuronal death called PANoptosis but also triggers microglia to adopt a pro-inflammatory (M1) phenotype, both in living organisms and in vitro

Ghazimoradi and Farivar, 2020)

Preclinical studies have consistently demonstrated that triggering ferroptosis effectively suppresses LC growth, underscoring its therapeutic potential (9,10)