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Nerves themselves are surrounded by insulating fatty sheath which is made up of myelin, a protein

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doi: 10.1038/nature06881 88 QuintanaFJBassoASIglesiasAHKornTFarezMFBettelliEet al

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This epigenetic mechanism is consistent with the broader Khavinson framework for bioregulator peptides, which proposes that short peptide sequences (27 amino acids) can penetrate nuclear membranes and interact directly with DNA or chromatin-associated proteins to modulate tissue-specific gene expression