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We note that if the request to split (or subdivide) an existing base MS-DRG into severity levels specifies the request is for either one of the two-way splits (1_23 or 12_3), in response to the specific request, we will evaluate the criteria for both of the two-way splits, however we do not also evaluate the criteria for a three-way split

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In the April 21, 2016 IFC (81 FR 23428 through 23438), referenced earlier in section III.G.1.a

Upon hypoxic insult, ATF4 upregulates the expression of M-CSF in hemangioma stem cells (HemSCs), to facilitate M2 macrophage polarization (183)