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Fibrillar structures were also observed, but they were not associated with copper ions, suggesting that copper promotes the formation of toxic oligomers that disrupt membranes ( Impaired autophagy plays an important role in IAPP toxicity, due to the accumulation of excessive amounts of IAPP oligomers intracellularly

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Date de mise jour : 9 juil

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Simultaneously, the significantly diminished proportion of Fe 3+ /Fe 2+ ratio further indicated that UPFB was utilized to exhaust GSH through a redox reaction (Figure 7F)