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Lowering homocysteine levels by supplementing with B vitamins has been shown to reduce the rate of brain atrophy in elderly people with mild cognitive impairment.[ref] Researchers have found that high homocysteine exacerbates amyloid-beta-induced cell death in the brain.[ref] Osteoporosis: Researchers think the connection between high homocysteine and osteoporosis could be due to dysregulation of the transsulfuration pathway rather than a problem with the remethylation of homocysteine

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Compared with the Aldh2 knockout mouse strain with a complete lack of ALDH2 function [3], the Aldh2*2 KI strain has some residual ALDH2 enzyme activity, which is relevant to the human ALDH2*2

2024;187:1109-1126.e21