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Hepatic impairment (OFV = 1.281), water volume 50 mL vs 120 mL (OFV = 3.328), age 65 years (OFV = 3.024), sex (OFV = 0.102) and renal impairment (OFV = 2.099) were excluded in the final model (in that order)

These results suggest that ISO injection causes oxidative stress in heart of rats, which is suppressed by the treatment of rosuvastatin

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