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28(5): 30711 Maehara M, Kinoshita S, Watanabe K

Proc Natl Acad Sci 90(23):1122711231 Ruckman J et al (1998) 2-Fluoropyrimidine RNA-based aptamers to the 165-amino acid form of vascular endothelial growth factor (VEGF165): Inhibition of receptor binding and VEGF-induced vascular permeability through interactions requiring the exon 7-encoded domain

This inherent restriction has significantly limited the availability of effective AD treatments and has triggered investigation into methods or strategies to bypass the BBB

Kent WJ, Sugnet CW, Furey TS, et al