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J Orthop Translat (2020) 22:92100
Despite the greater risk of nephrotoxicity associated with the drug, a retrospective study observed a lower recurrence rate when compared with intravenous methylprednisolone, in addition to the shorter therapeutic course.79,80 Other described treatments include intravenous immunoglobulin, mepolizumab, dupilumab and plasmapheresis, whit success described in a few case reports.27 Specific antiviral treatment (e.g., ganciclovir) is a controversial subject, and although not recommended by some authors,75 if signs and symptoms are suggestive and there is confirmation of viral reactivation, specific immunoglobulins and antivirals should be tried
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Albumin affinity purification and contamination by macroglobulins: Purification of affinity is a useful tool for removing and cleaning up the excess albumin and macroglobulin contamination from samples since these components may obscure or hinder subsequent analysis steps (like mass spectrometry) as well as immunoprecipitation One method of purification which can be used to get rid of these pollutants either before or after additional steps of purification is A affinity chromatography using blue sepharose
