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This stability makes it a highly potent reagent for sustaining cellular signaling in culture media and animal models

Data availability The expression datasets analyzed for this study can be downloaded from the TCGA database ( The correlation between drug sensitivity and mRNA expression was analyzed using the Gene Set Cancer Analysis (GSCA) database ( The relationships between sorafenib and four ferroptosis-related genes in RCC were analyzed using the Genomics of Drug Sensitivity in Cancer (GDSC) database ( All data generated or analyzed during this study are included in this article

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For live imaging, the temperature was maintained at 37 C with 5% CO 2 using an environmental control chamber (Life Imaging Services and Solent Scientific)