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43,44 Glucose-6-phosphate dehydrogenase (G6PD) that exists as either an active dimer or an inactive monomer dehydrogenates G6P to yield 6-phosphogluconolactone (6-PGL) and NADPH in the first reaction
The therapeutic effects of Clostridium and their metabolites (e.g., SCFAs, butyrate, PCS, and vitamin K2) are mediated through a synergistic network of mechanisms, with precise correction of immune dysregulation standing as the most pivotal value
401 These findings suggest that Schwann cells under impaired metabolic conditions release pathologic EVs that promote nerve degeneration and DPN, whereas homeostatic EVs may facilitate nerve repair
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