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Suspected adverse drug reactions, including possible metformin-associated B12 deficiency, can be reported via the MHRA Yellow Card scheme (yellowcard.mhra.gov.uk)
The risk of developing severe side effects is very low with only 1 in 500 patients experiencing serious adverse events and the potential benefits of the treatment are very high, especially for those who have found that no other treatments are effective
Dietary supplements should not be used as a substitute for a varied, healthy diet
Tanshinone IIA is superior to paricalcitol in ameliorating tubulointerstitial fibrosis through regulation of VDR/Wnt/-catenin pathway in rats with diabetic nephropathy
[DOI] [PMC free article] [PubMed] [Google Scholar] 105.Barisic I., Balenovic D., Klicek R., Radic B., Nikitovic B., Drmic D., Udovicic M., Strinic D., Bardak D., Berkopic L., et al
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