in the 1980s from met-enkephalin scaffold The compound was among the earliest synthetic peptides characterized as engaging the then-unknown growth hormone secretagogue receptor a receptor eventually identified as GHS-R1a, the endogenous target of ghrelin
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Binding to the IGF1R initiates intracellular signaling
Liu J, Wang W, Liu K, Wan D, Wu Z, Cao Z, Luo Y, Xiao C, Yin M
