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May also interact with FGF pathways based on observed effects on fibroblast proliferation

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NNMT is upregulated in the white adipose tissue of obese animals and humans, and its activity is mechanistically linked to depleted cellular NAD+ and SAM pools

Long-read genome sequencing could facilitate the discovery of additional SLOCA-causing gene variants, and validation of surrogate biomarkers would promote the identification of disease-modifying drugs

Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1