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This could include anything from ataxia and slowed reactions, to psychomotor retardation, mental retardation and seizures

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The MGF isoform has a unique E domain because of a 49 bp insert in exon 5 (52 bp in the rodent) that results in a reading frame shift and a unique C-terminal peptide producing a distinct mature isoform that is detectable in tissue specifically after mechanical strain and/or damage, rather than being constitutively expressed like the predominant IGF-1Ea isoform

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