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The mRNA delivery of polymer nanoparticles can effectively induce the expression of Phosphatase and Tensin Homolog (PTEN) in cancer cells, based on this, the PTEN mRNA nanoparticles can reverse the immunosuppressive tumor microenvironment by promoting CD8 + T cells infiltration into tumor tissues and reducing Tregs and MDSCs, showing highly effective anti-tumor effects when used in combination with PD-1 antibodies (216)
Safflower oil, almonds, sunflower oil, and wheat germ oil are good sources of alpha-tocopherol
The mitochondrial fusion/fission-associated proteins Mfn2 and Drp1 have been proposed to function as downstream nuclear transcription factors in the PGC-1-mediated mitochondrial biogenesis process (Peng et al., 2017)
L-carnitine reduces inflammatory response via the transfer of -oxidized long-chain fatty acids in mitochondria and the excretion of toxic substances in fatty acid metabolism (69)
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