There are two isotypes of GLS, which are encoded by two genes in mammals, renal type GLS1 and living type GLS2
It is modeled after a naturally occurring protein fragment found within gastric juice and has attracted considerable scientific attention for its involvement in regenerative and healing pathways
krlec, K., Ruman, R., Jarc, E., Sikiri, P., vajger, U., Petan, T., Perii Nanut, M., trukelj, B., & Berlec, A
Importantly, the same stimulator of interferon genes (STING) that was shown to be involved in the suppression of tumor angiogenesis and vessel normalization (161) also contributed to tumor monocyte reprogramming and NK cell-mediated anti-tumor immunity (162)
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