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It is distributed rapidly to tissues with high metabolic activity like the liver, kidneys, and muscles

Published Research on 5-Amino-1MQ Foundational DIO Mouse Study Neelakantan et al., Biochemical Pharmacology (2018) This paper introduced 5-Amino-1MQ as a selective and membrane-permeable small molecule inhibitor of NNMT and tested it in 3T3-L1 adipocytes and in male C57BL/6J mice maintained on a high-fat diet

Research with NNMT blockers such as 5-amino-1MQ has demonstrated increased GLUT4 expression, greater glucose utilization, and enhanced metabolic activity