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Acknowledgments Authors want to thank Germaine Pugh and Cassia McClain for their invaluable help in preparing the manuscript, and Jessica Michelle Vasquez-Soltero for processing the gene profiling data

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A recent report has identified an iron dependent non-apoptotic form of cell death termed ferroptosis [137] and studies on primary hepatocytes in culture seem to suggest that this form of cell death may play a role in APAP-induced hepatocyte injury [138]