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376 While detailed spectroscopic studies have led to atomic-level models of the different holo RcnR species that define residues beyond the W-X-Y-Z motif, the lack of a structure hinders our understanding of the allosteric mechanism of transcriptional derepression by RcnR

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However, no significant change in p-JNK protein level was observed in HUVECs (Figure 6)

Expression profiles are redirected towards signatures characteristic of young tissues (Pickart & Margolina, Int J Mol Sci 2018)

The mechanism likely relates to changes in appetite regulation and energy metabolism