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The findings showed that using bispecific Ab (anti-EGFR and anti-c-Met) could suppress growth in anti-EGFR resistant cells more efficiently compared to anti-EGFR agents, such as gefitinib, erlotinib, and so on [149]

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No human safety data : The complete absence of human clinical trials means the safety profile, side effects, optimal dosing, and pharmacokinetics in humans are entirely unknown Animal-to-human translation is uncertain : Metabolic differences between mice and humans mean that the magnitude of effects (e.g., weight loss, grip strength improvement) may not translate

Archived from the original on December 10, 2023