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In the initial stage of carcinogenesis, ROS play a variety of roles, including mediating the activation of carcinogens, causing DNA damage, and interfering with responses to DNA damage [37,38,39]

Couto N, Wood J, Barber J

Eur J Dermatol

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A phase 1 clinical trial evaluated the efficacy of locally administering anti-CTLA-4 into TDLNs in patients with stage I/II melanoma (NCT04274816) ( Figure 3 )