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Similarly, the protective effects of metformin on subchondral bone are indirect, occuring through cartilage integrity preservation and oxidative stress reduction 54

This is consistent with the original description of the Johnsen scoring system, which emphasizes germ cell maturation rather than morphometric parameters 31

If you are consistently cutting your sleep short or living in a state of high-stress "fight or flight," your body may struggle to replenish its antioxidant stores

Brain neuroimaging (MRI) findings ranged from normal to delayed myelination and features consistent with Leigh syndrome [55-57]

As with any skincare product, results can vary, and its recommended to do a patch test before full application