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doi: 10.1007/s00018-020-03656-y 53 BedardKKrauseK-H

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Its cytotoxic properties result from the strong electrophilic nature arising from its adjacent carbonyl groups, allowing spontaneous reactions with protein amino acid residues (e.g., arginine, lysine, and cysteine), phospholipids, and nucleic acids (e.g., guanine) to form advanced glycation end products (AGEs) that impair the functionality of their biological targets [22]

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