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What has been more difficult to explain is why such diverse pressures so often lead to similar functional outcomes: reduced flexibility, altered learning, sensory overload, and difficulty recovering from stress

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The introduction of advanced conjugation systems (e.g., SpyTag/SpyCatcher) and rational design using liposomes, hydrogels, or metalorganic frameworks (MOFs) can achieve precise modulation of bacterial surfaces, improving tumor targeting and drug delivery

We incorporate these findings into a broader model of GLP1 medication response, and demonstrate the ability to stratify patients by efficacy and side effect risk